MMAE-d8

MMAE-d8 is a deuterated labeled MMAE, a potent mitotic inhibitor and a tubulin inhibitor.

Product Specifications

CAS Number

[2070009-72-0]

Product Name Alternative

Monomethyl auristatin E-d8; Deuterated labeled MMAE

UNSPSC

12352005

Hazard Statement

H300+H330, H340, H360, H370, H372, H412

Target

ADC Payload; Microtubule/Tubulin

Type

Isotope-Labeled Compounds

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

99.29

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N1[C@H]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C2=CC=CC=C2)=O)CCC1)=O)C)[C@@]([2H])(NC([C@@H](NC)C(C)C)=O)C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H]

Molecular Formula

C39H59D8N5O7

Molecular Weight

726.03

Precautions

H300+H330, H340, H360, H370, H372, H412

References & Citations

[1]Li F, et al. Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models. Cancer Res. 2016 May 1;76 (9) :2710-9.