MMAE-d8
Product Specifications
UNSPSC Description
MMAE-d8 is a deuterated labeled MMAE, a potent mitotic inhibitor and a tubulin inhibitor.
Target Antigen
ADC Cytotoxin; Microtubule/Tubulin
Type
Isotope-Labeled Compounds
Related Pathways
Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage;Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N1[C@H]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C2=CC=CC=C2)=O)CCC1)=O)C)[C@@]([2H])(NC([C@@H](NC)C(C)C)=O)C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H]
Molecular Weight
726.03
References & Citations
[1]Li F, et al. Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models. Cancer Res. 2016 May 1;76(9):2710-9.
Shipping Conditions
Room Temperature
Clinical Information
No Development Reported
CAS Number
2070009-72-0
Available Sizes
Curated Selection
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