DUB-IN-8
Product Specifications
UNSPSC Description
DUB-IN-8 (Compound 8q) is an inhibitor for Chlamydia deubiquitinase 1 (DUB1), with IC50 of 7.7 μM. DUB-IN-8 exhibits antimicrobial activity, inhibits the chlamydial inclusions with an IIC50 (the concentration to induce 50% inclusion inhibition) of 8.5 μg/mL[1].
Target Antigen
Bacterial; Deubiquitinase
Type
Reference compound
Related Pathways
Anti-infection;Cell Cycle/DNA Damage
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dub-in-8.html
Smiles
O=C(NCC1=CC=C(C(NC2[C@@H]3C[C@@H]4C[C@H]2C[C@@H](C4)C3)=O)C=C1)C5=CN=C(C#N)N=C5
Molecular Weight
415.49
References & Citations
[1]Zimmermann T, et al., Structure-Based Design and Synthesis of Covalent Inhibitors for Deubiquitinase and Acetyltransferase ChlaDUB1 of Chlamydia trachomatis. J Med Chem. 2024 Jun 19.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163769/DUB-IN-8-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163769/
Clinical Information
No Development Reported
Curated Selection
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