DUB-IN-8

DUB-IN-8 (Compound 8q) is an inhibitor for Chlamydia deubiquitinase 1 (DUB1), with IC50 of 7.7 μM. DUB-IN-8 exhibits antimicrobial activity, inhibits the chlamydial inclusions with an IIC50 (the concentration to induce 50% inclusion inhibition) of 8.5 μg/mL[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial; Deubiquitinase

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/dub-in-8.html

Smiles

O=C(NCC1=CC=C(C(NC2[C@@H]3C[C@@H]4C[C@H]2C[C@@H](C4)C3)=O)C=C1)C5=CN=C(C#N)N=C5

Molecular Formula

C24H25N5O2

Molecular Weight

415.49

References & Citations

[1]Zimmermann T, et al., Structure-Based Design and Synthesis of Covalent Inhibitors for Deubiquitinase and Acetyltransferase ChlaDUB1 of Chlamydia trachomatis. J Med Chem. 2024 Jun 19.