GNE-493

GNE-493 is a potent, selective, and orally available dual pan-PI3-kinase/mTOR inhibitor with IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR.

Product Specifications

CAS Number

[1033735-94-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MTOR; PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/GNE-493.html

Purity

99.81

Solubility

DMSO : 35.71 mg/mL (ultrasonic)

Smiles

OC(C)(C)C1=CC2=C(S1)C(N3CCOCC3)=NC(C4=CN=C(N)N=C4)=N2

Molecular Formula

C17H20N6O2S

Molecular Weight

372.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Sutherlin DP, et al. Discovery of (thienopyrimidin-2-yl) aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancer. J Med Chem. 2010 Feb 11;53 (3) :1086-97.