Phenylpyruvic acid (sodium)

Phenylpyruvic acid sodium is a endogenous metabolite that participates in the synthesis of 3-phenyllactic acid (PLA) by lactate dehydrogenase. Phenylpyruvic acid is a precursor of the antifungal compound phenyllactic acid. Phenylpyruvic acid can improve the antifungal activity of eight lactic acid bacterial strains through the addition into a dedined growth medium. Phenylpyruvic acid demonstrates improved inhibitory activity against fungal bread contaminants Aspergillus niger and Penicillium roqueforti. Phenylpyruvic acid affects enzyme activity of the pentose phosphate pathway involved in the oxidative phase in rat brain homogenates. Phenylpyruvic acid can reduce glucose-6-phosphate dehydrogenase activity[1][2].

Product Specifications

CAS Number

[114-76-1]

Product Name Alternative

Sodium phenylpyruvate

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; PDI

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/phenylpyruvic-acid-sodium.html

Purity

98.24

Solubility

H2O : 5.83 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C(CC1=CC=CC=C1)=O)O[Na]

Molecular Formula

C9H7NaO3

Molecular Weight

186.14

Precautions

H302, H315, H319, H335

References & Citations

[1]Valerio F, et al. Improvement of the antifungal activity of lactic acid bacteria by addition to the growth medium of phenylpyruvic acid, a precursor of phenyllactic acid. Int J Food Microbiol. 2016 Apr 2;222:1-7.|[2]Rosa, A. P., et al., (2012) . Phenylpyruvic acid decreases glucose-6-phosphate dehydrogenase activity in rat brain. Cellular and molecular neurobiology, 32 (7), 1113–1118.