Kaempferol-7-O-rhamnoside

Kaempferol-7-O-rhamnoside is a PD-1/PD-L1 inhibitor and farnesoid X receptor (FXR) agonist. Kaempferol-7-O-rhamnoside demonstrates cardioprotective potential targeting the AMPKα1 signaling pathway. Kaempferol-7-O-rhamnoside significantly upregulates the mRNA expression of AMPKα1 in H9c2 cardiomyocytes. Kaempferol-7-O-rhamnoside reverses APAP-induced reduction of glutathione (GSH) content and increase of ROS production in L02 cells. Kaempferol-7-O-rhamnoside has the potential for heart failure[1][2][3].

Product Specifications

CAS Number

[20196-89-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

AMPK; FXR; PD-1/PD-L1; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/kaempferol-7-o-rhamnoside.html

Purity

99.18

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C(O)=C(C2=CC=C(O)C=C2)OC3=CC(O[C@H]4[C@@H]([C@@H]([C@H]([C@H](C)O4)O)O)O)=CC(O)=C13

Molecular Formula

C21H20O10

Molecular Weight

432.38

Precautions

H302, H315, H319, H335

References & Citations

[1]Kim JH, et al. Kaempferol and Its Glycoside, Kaempferol 7-O-Rhamnoside, Inhibit PD-1/PD-L1 Interaction In Vitro. Int J Mol Sci. 2020 May 3;21 (9) :3239. |[2]Li Z, et al. Decoding the anti-heart failure effects of Xinbao Pills: AMPKα1 activation and active compound screening. Phytomedicine. 2025 Sep;145:157016. |[3]Liu K, et al. Identification of a novel farnesoid X receptor agonist, kaempferol-7-O-rhamnoside, a compound ameliorating drug-induced liver injury based on virtual screening and in vitro validation. Toxicol Appl Pharmacol. 2022 Nov 1;454:116251.