Zharp1-211
Product Specifications
UNSPSC Description
Zharp1-211 is a potent inhibitor of RIPK1 kinase. Zharp1-211 significantly reduces the expression of JAK/STAT1-mediated chemokines and MHC class II molecules in intestinal epithelial cells[1].
Target Antigen
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/zharp1-211.html
Solubility
DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(OC1CCOCC1)N2C3=CC(C(C=C4)=CN5C4=NC(NC(C6CC6)=O)=C5)=CN=C3CC2
Molecular Weight
447.49
References & Citations
[1]Yu X, et al. A novel RIPK1 inhibitor reduces GVHD in mice via a nonimmunosuppressive mechanism that restores intestinal homeostasis. Blood. 2023 Mar 2;141(9):1070-1086.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161060/Zharp1-211-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161060/Zharp1-211-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2258671-41-7
Available Sizes
Curated Selection
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