NSC697923
Product Specifications
UNSPSC Description
NSC697923 is a potent UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) inhibitor. NSC697923 induces neuroblastoma (NB) cell death via promoting nuclear importation of p53 in p53 wild-type NB cells. NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 inhibits DNA damage and NF-κB signaling. Antitumor activity[1][2].
Target Antigen
Apoptosis; E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Apoptosis;Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc697923.html
Smiles
O=S(C1=CC=C([N+]([O-])=O)O1)(C2=CC=C(C)C=C2)=O
Molecular Weight
267.26
References & Citations
[1]Cheng J, et al. A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 2014;5(2):e1079. Published 2014 Feb 20.|[2]Hodge CD, et al. Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting. ACS Chem Biol. 2015;10(7):1718-1728.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13811/NSC697923-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13811/NSC697923-SDS-MedChemExpress.pdf
CAS Number
343351-67-7
Available Sizes
Curated Selection
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