NSC697923

NSC697923 is a potent UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) inhibitor. NSC697923 induces neuroblastoma (NB) cell death via promoting nuclear importation of p53 in p53 wild-type NB cells. NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 inhibits DNA damage and NF-κB signaling. Antitumor activity[1][2].

Product Specifications

CAS Number

[343351-67-7]

UNSPSC

12352005

Hazard Statement

H302, H318

Target

Apoptosis; E1/E2/E3 Enzyme

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nsc697923.html

Concentration

10mM

Purity

99.93

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=C([N+]([O-])=O)O1)(C2=CC=C(C)C=C2)=O

Molecular Formula

C11H9NO5S

Molecular Weight

267.26

Precautions

H302, H318

References & Citations

[1]Cheng J, et al. A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 2014;5 (2) :e1079. Published 2014 Feb 20.|[2]Hodge CD, et al. Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting. ACS Chem Biol. 2015;10 (7) :1718-1728.