Cobicistat
Cobicistat is a potent and selective inhibitor of cytochrome P450 3A (CYP3A) enzymes with IC50s of 30-285 nM. Cobicistat is a pharmacokinetic enhancer which increases the overall absorption of several HIV medications.
Product Specifications
CAS Number
1004316-88-4
Product Name Alternative
GS-9350
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Cytochrome P450; HIV
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/Cobicistat.html
Purity
99.77
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
CN(C(N[C@@H](CCN1CCOCC1)C(N[C@@H](CC2=CC=CC=C2)CC[C@@H](NC(OCC3=CN=CS3)=O)CC4=CC=CC=C4)=O)=O)CC5=CSC(C(C)C)=N5
Molecular Formula
C40H53N7O5S2
Molecular Weight
776.02
Precautions
H315, H319, H335
References & Citations
[1]Lianhong Xu, et al. Cobicistat (GS-9350) : A Potent and Selective Inhibitor of Human CYP3A as a Novel Pharmacoenhancer. ACS Med. Chem. Lett., 2010, 1 (5), pp 209–213|[2]Temesgen Z. Cobicistat, a pharmacoenhancer for HIV treatments. Drugs Today (Barc) . 2013 Apr;49 (4) :233-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
CYP3; HIV-1
Available Sizes
Frequently Asked Questions
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