Cobicistat

Cobicistat is a potent and selective inhibitor of cytochrome P450 3A (CYP3A) enzymes with IC50s of 30-285 nM. Cobicistat is a pharmacokinetic enhancer which increases the overall absorption of several HIV medications.

Product Specifications

CAS Number

[1004316-88-4]

Product Name Alternative

GS-9350

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Cytochrome P450; HIV

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/Cobicistat.html

Purity

99.77

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

CN(C(N[C@@H](CCN1CCOCC1)C(N[C@@H](CC2=CC=CC=C2)CC[C@@H](NC(OCC3=CN=CS3)=O)CC4=CC=CC=C4)=O)=O)CC5=CSC(C(C)C)=N5

Molecular Formula

C40H53N7O5S2

Molecular Weight

776.02

Precautions

H315, H319, H335

References & Citations

[1]Lianhong Xu, et al. Cobicistat (GS-9350) : A Potent and Selective Inhibitor of Human CYP3A as a Novel Pharmacoenhancer. ACS Med. Chem. Lett., 2010, 1 (5), pp 209–213|[2]Temesgen Z. Cobicistat, a pharmacoenhancer for HIV treatments. Drugs Today (Barc) . 2013 Apr;49 (4) :233-7.