Erlotinib-d6 (hydrochloride)

Erlotinib-d6 hydrochloride a deuterium labeled Erlotinib Hydrochloride. Erlotinib Hydrochloride inhibits purified EGFR kinase with an IC50 of 2 nM[1]. Erlotinib-d6 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[1189953-78-3]

Product Name Alternative

CP-358774-d6 (hydrochloride) ; NSC 718781-d6 (hydrochloride) ; OSI-774-d6 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302

Target

Autophagy; EGFR

Type

Isotope-Labeled Compounds

Related Pathways

Autophagy; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Purity

98.13

Solubility

10 mM in DMSO|H2O : ≥ 0.1mg/mL

Smiles

[2H]C([2H])([2H])OCCOC1=CC2=NC=NC(NC3=CC=CC(C#C)=C3)=C2C=C1OCCOC([2H])([2H])[2H].[H]Cl

Molecular Formula

C22H18D6ClN3O4

Molecular Weight

435.93

Precautions

P264-P270-P330-P501

References & Citations

[1]Moyer JD, et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 1997 Nov 1;57 (21) :4838-48.