Selfotel

Selfotel (CGS 19755) is a selective and competitive antagonist at N-methyl-D-aspartate (NMDA) -preferring receptor. CGS 19755 inhibits the binding of [3H]-3- (2-carboxypiperazin-4-yl) propyl-1-phosphonic acid to NMDA-type receptors with an IC50 of 50 nM[1][2].

Product Specifications

CAS Number

[110347-85-8]

Product Name Alternative

CGS 19755

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/selfotel.html

Purity

99.67

Solubility

H2O : 10 mg/mL (ultrasonic)

Smiles

O=C([C@@H]1NCC[C@H](CP(O)(O)=O)C1)O

Molecular Formula

C7H14NO5P

Molecular Weight

223.16

Precautions

H302, H315, H319, H335

References & Citations

[1]D A Bennett, et al. Behavioral pharmacological profile of CGS 19755, a competitive antagonist at N-methyl-D-aspartate receptors. J Pharmacol Exp Ther. 1989 Aug;250 (2) :454-60.|[2]J Lehmann, et al. CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist. J Pharmacol Exp Ther. 1988 Jul;246 (1) :65-75.|[3]M A Pérez-Pinzón, et al. Correlation of CGS 19755 neuroprotection against in vitro excitotoxicity and focal cerebral ischemia. J Cereb Blood Flow Metab. 1995 Sep;15 (5) :865-76.