TPBG/5T4, Cynomolgus (HEK293, His)

TPBG/5T4 protein blocks Wnt3a-dependent LRP6 internalization by indirectly interacting with LRP6, thereby potentially inhibiting Wnt/β-catenin signaling. This unique mechanism suggests that TPBG/5T4 plays a crucial role in regulating the Wnt/β-catenin pathway by disrupting LRP6 internalization and affecting downstream signaling. TPBG/5T4 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TPBG/5T4 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TPBG/5T4 Protein, Cynomolgus (HEK293, His) is 321 a.a., with molecular weight of 55-80 kDa.

TSSASSSSSS APFLASAASA QPPLPDQCPA LCECSEAART VKCVNRNLTE VPTDLPLYVR NLFLTGNQLA VLPAGAFARR PPLAELAALN LSGSRLDEVR GGAFEHLPSL RQLDLSHNPL AYLSPFAFSG SNASISAPSP LVELILNHIV PPDDKRQNRS FEGMVAAALV AGRALQGLHL LELASNHFLY LPRDVLAQLP SLRYLDLSNN SLVSLTYVSF RNLTHLESLH LEDNALKVLH NGTLAELQGL PHVRVFLDNN PWVCDCHMAD MVTWLKQTGV VQGKDRLTCA FPEKMRNRVL LELNSADLDC DPILPPSLQT S