PF-06426779
Product Specifications
UNSPSC Description
PF-06426779 is a potent and selective inhibitor of interleukin?1 receptor associated kinase 4 (IRAK4), with an IC50 of 0.3 nM[1].
Target Antigen
IRAK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pf-06426779.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC2=C(C(OC[C@H]([C@H](C)[C@@H]3F)NC3=O)=NC=C2)C=C1OC)N
Molecular Weight
347.34
References & Citations
[1]Lee KL, et, al. Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. J Med Chem. 2017 Jul 13; 60(13): 5521-5542.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-123854/PF-06426779-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-123854/PF-06426779-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1817628-40-2
Available Sizes
Curated Selection
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