PF-06426779

PF-06426779 is a potent and selective inhibitor of interleukin 1 receptor associated kinase 4 (IRAK4), with an IC50 of 0.3 nM[1].

Product Specifications

CAS Number

[1817628-40-2]

UNSPSC

12352005

Target

IRAK

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pf-06426779.html

Concentration

10mM

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC2=C(C(OC[C@H]([C@H](C)[C@@H]3F)NC3=O)=NC=C2)C=C1OC)N

Molecular Formula

C17H18FN3O4

Molecular Weight

347.34

References & Citations

[1]Lee KL, et, al. Discovery of Clinical Candidate 1-{[ (2S,3S,4S) -3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. J Med Chem. 2017 Jul 13; 60 (13) : 5521-5542.