TP-004
Product Specifications
UNSPSC Description
TP-004 is a potent and reversible inhibitor of methionine aminopeptidase 2 (MetAP2), with an IC50 of 6 nM[1].
Target Antigen
MetAP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/tp-004.html
Purity
98.89
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O[C@H]1CN(C2=NC=C(C3=CC(C(F)(F)F)=CC4=C3C=NN4)C(C)=N2)CC1
Molecular Weight
363.34
References & Citations
[1]Cheruvallath, Z., et al. Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design—Part 1. Bioorganic & Medicinal Chemistry Letters, 26(12), 2774–2778.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-120868/TP-004-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-120868/TP-004-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1454299-21-8
Available Sizes
Curated Selection
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