TP-004
TP-004, a chemical probe, is a potent and reversible inhibitor of methionine aminopeptidase 2 (MetAP2), with an IC50 of 6 nM[1].
Product Specifications
CAS Number
[1454299-21-8]
UNSPSC
12352005
Target
MetAP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/tp-004.html
Concentration
10mM
Purity
99.17
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O[C@H]1CN(C2=NC=C(C3=CC(C(F)(F)F)=CC4=C3C=NN4)C(C)=N2)CC1
Molecular Formula
C17H16F3N5O
Molecular Weight
363.34
References & Citations
[1]Cheruvallath, Z., et al. Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design—Part 1. Bioorganic & Medicinal Chemistry Letters, 26 (12), 2774–2778.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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