Des-Leu10-angiotensin I

Des-Leu10-angiotensin I is a nonapeptide that inhibits rabbit lung angiotensin-converting enzyme peptidyl-dipeptide hydrolase with a Ki value of 31 μM, which is generated from angiotensin I by the action of carboxypeptidase-like activities residing in the human platelet and mast cell[1].

Product Specifications

CAS Number

[34273-12-6]

UNSPSC

12352209

Target

Drug Metabolite

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/des-leu10-angiotensin-i.html

Smiles

OC(C=C1)=CC=C1C[C@H](NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CC(O)=O)=O)=O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CN=CN2)C(N3[C@@H](CCC3)C(N[C@H](C(N[C@H](C(O)=O)CC4=CN=CN4)=O)CC5=CC=CC=C5)=O)=O)=O)=O

Molecular Formula

C56H78N16O13

Molecular Weight

1183.32

References & Citations

[1]Snyder RA, et al. Inhibition of angiotensin-converting enzyme by des-Leu10-angiotensin I: a potential mechanism of endogenous angiotensin-converting enzyme regulation. Biochim Biophys Acta. 1986 May 12;871 (1) :1-5.