SDMA (p-hydroxyazobenzene-p′-sulfonate)

SDMA p-hydroxyazobenzene-p′-sulfonate is the p-hydroxyazobenzene-p′-sulfonate salt form of SDMA (HY-101410) . SDMA p-hydroxyazobenzene-p′-sulfonate is an endogenous inhibitor of nitric oxide synthase (NO synthase) activity. SDMA p-hydroxyazobenzene-p′-sulfonate is an activator for NF-κB, and promotes the expression of IL-6 and TNF-α. SDMA p-hydroxyazobenzene-p′-sulfonate is stable in serum and plasma, and can be used as a kidney biomarker of hepatic and renal dysfunction[1][2][3].

Product Specifications

CAS Number

[1266235-58-8]

Product Name Alternative

Symmetric dimethylarginine (p-hydroxyazobenzene-p′-sulfonate) ; NG, NG'-Dimethyl-L-arginine (p-hydroxyazobenzene-p′-sulfonate)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Endogenous Metabolite; NF-κB; NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sdma-p-hydroxyazobenzene-p-sulfonate.html

Smiles

OC(C=C1)=CC=C1/N=N/C2=CC=C(C=C2)S(=O)(O)=O.OC([C@@H](N)CCC/N=C(NC)/NC)=O.[0.5]

Molecular Formula

C12H10N2O4S.1/2C8H18N4O2

Molecular Weight

378.41

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Bode-Böger SM, et al. Symmetrical dimethylarginine: a new combined parameter for renal function and extent ofcoronary artery disease.|[2]Schepers E, et al. Symmetric dimethylarginine as a proinflammatory agent in chronic kidney disease.Clin J Am Soc Nephrol. 2011 Oct;6 (10) :2374-83.|[3]Nabity MB, et al. Symmetric Dimethylarginine Assay Validation, Stability, and Evaluation as a Marker for the EarlyDetection of Chronic Kidney Disease in Dogs. J Vet Intern Med. 2015 Jul-Aug;29 (4) :1036-44.|[4]Veldink H, et al. Effects of chronic SDMA infusion on glomerular filtration rate, blood pressure, myocardial function and renal histology in C57BL6/J mice. Nephrol Dial Transplant. 2013 Jun;28 (6) :1434-9.