SARS-CoV-2 Mpro-IN-23
SARS-CoV-2 Mpro-IN-23 (Compound 2) is an inhibitor for SARS-CoV-2 main protease (Mpro), which inhibits wildtype Mpro and mutant Mpro variants, with IC50 of 0.057-0.92 μM. SARS-CoV-2 Mpro-IN-23 inhibits the post-entry viral processes of wild-type SARS-CoV-2 single-round infectious particles (SRIPs), suppresses the viral replication of Mpro wildtype and Mpro mutants with EC50 of 0.02-0.52 μM[1].
Product Specifications
UNSPSC
12352005
Target
SARS-CoV; Virus Protease
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/sars-cov-2-mpro-in-23.html
Smiles
C[C@@]1(CC[C@]2([C@@]([H])(C1)C([C@]3(CC2)C)=CC(C4[C@]3(CC[C@@]5([C@@]4(CC[C@@H](C5(C)C)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O)C(ONC(C(OC)=O)CCSC)=O)O)O)C(ONC(CCSC)C(OC)=O)=O)C)[H])C)=O)C)C(O)=O
Molecular Formula
C54H84N2O20S2
Molecular Weight
1145.38
References & Citations
[1]Le UNP, et al., Glycyrrhizic acid conjugates with amino acid methyl esters target the main protease, exhibiting antiviral activity against wild-type and nirmatrelvir-resistant SARS-CoV-2 variants. Antiviral Res. 2024 Jul;227:105920.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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