Condurango glycoside A
Condurango glycoside A is an activator of p53. Condurango glycoside A initiates ROS generation and up-regulates p53 expression. Condurango glycoside A induces apoptosis and pre-mature senescence associated with DNA damage in HeLa cells[1].
Product Specifications
CAS Number
11051-90-4
UNSPSC
12352005
Target
Apoptosis; MDM-2/p53; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/condurango-glycoside-a.html
Purity
95.47
Smiles
C[C@@H]1[C@@H](O)[C@@H](OC)[C@@H](O)[C@H](O[C@@H]2[C@@H](C)O[C@@H](O[C@@H]3[C@@H](C)O[C@@H](O[C@H]4CC[C@@]5(C)C(CCC6C5[C@H](OC(C)=O)[C@@H](OC(/C=C/C7=CC=CC=C7)=O)[C@@]8(C)[C@]6(O)CC[C@@H]8C(C)=O)C4)C[C@@H]3OC)C[C@@H]2OC)O1
Molecular Formula
C53H78O17
Molecular Weight
987.18
References & Citations
[1]Bishayee K, et al. Condurango-glycoside-A fraction of Gonolobus condurango induces DNA damage associated senescence and apoptosis via ROS-dependent p53 signalling pathway in HeLa cells. Mol Cell Biochem. 2013 Oct;382 (1-2) :173-83.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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