JNJ-47117096 hydrochloride

JNJ-47117096 hydrochloride is potent and selective MELK inhibitor, with an IC50 of 23 nM, also effectively inhibits Flt3, with an IC50 of 18 nM.

Product Specifications

CAS Number

[1610536-69-0]

Product Name Alternative

MELK-T1 hydrochloride

UNSPSC

12352005

Target

FLT3; MELK

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/JNJ-47117096_hydrochloride.html

Purity

99.68

Solubility

DMSO : ≥ 250 mg/mL|H2O : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC1=CC=C2CCNCCC2=C1)C3=CC=C(C4=CNN=C4)C=C3OC.Cl

Molecular Formula

C21H23ClN4O2

Molecular Weight

398.89

References & Citations

[1]Johnson CN, et al. Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase. ACS Med Chem Lett. 2014 May 23;6 (1) :25-30.|[2]Beke L, et al. MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells. Biosci Rep. 2015 Oct 2;35 (6) . pii: e00267.