GPR35 agonist 4

GPR35 agonist 4 (compound 10) is a potent GPR35 agonist with an pEC50 of 5.86. GPR35 agonist 4 shows high potency human and rat GPR35. Mutation of arginine 3.36 eliminates agonist function of GPR35 agonist 4[1].

Product Specifications

CAS Number

[871085-49-3]

UNSPSC

12352005

Target

GPR35

Type

Reference compound

Related Pathways

GPCR/G Protein

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/gpr35-agonist-4.html

Purity

99.0

Solubility

DMSO : 27.9 mg/mL (ultrasonic)

Smiles

O=C(NC(S/1)=O)C1=C\C2=CC=C(C=C2)OCC(O)=O

Molecular Formula

C12H9NO5S

Molecular Weight

279.27

References & Citations

[1]Jenkins L, et al. Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα₁₃ and β-arrestin-2. Br J Pharmacol. 2011 Feb;162 (3) :733-48.