IL-17-IN-1
IL-17-IN-1 (26) is an orally active IL-17 inhibitor, with IC50 values of 0.013 μM and 0.004 μM for IL-17A and IL-6 release, respectively. IL-17-IN-1 (26) effectively reduces knee swelling in a rat arthritis model[1].
Product Specifications
UNSPSC
12352005
Target
Interleukin Related
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/il-17-in-1.html
Smiles
O=C1N[C@H](C(F)(F)F)CN1[C@H](COC)C2=CC3=NC([C@H](C4CCC(F)(CC4)F)NC(/C(F)=C\C5CC5)=O)=CN3N=C2
Molecular Formula
C26H30F6N6O3
Molecular Weight
588.55
References & Citations
[1]Juraj Velcicky, et al. Discovery and In Vivo Exploration of 1,3,4-Oxadiazole and α-Fluoroacrylate Containing IL-17 Inhibitors. J Med Chem. 2024 Sep 26;67 (18) :16692-16711.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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