3α,21-Dihydroxy-5α-pregnan-20-one
3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABAA receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro.
Product Specifications
CAS Number
[567-02-2]
Product Name Alternative
THDOC
UNSPSC
12352211
Hazard Statement
H301+H311+H331
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/3α-21-dihydroxy-5α-pregnan-20-one.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@]12[C@H](CC[C@]1([C@@]3(CC[C@]4(C[C@@H](CC[C@@]4([C@]3(CC2)[H])C)O)[H])[H])[H])C(CO)=O
Molecular Formula
C21H34O3
Molecular Weight
334.49
Precautions
H301+H311+H331
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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