Clofilium tosylate
Clofilium tosylate, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Antiarrhythmic agent[1].
Product Specifications
CAS Number
[92953-10-1]
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; Potassium Channel
Type
Reference compound
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Clofilium_tosylate.html
Concentration
10mM
Purity
99.60
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 1.59 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CCCCCCC[N+](CC)(CCCCC1=CC=C(Cl)C=C1)CC.O=S(C2=CC=C(C)C=C2)([O-])=O
Molecular Formula
C28H44ClNO3S
Molecular Weight
510.17
Precautions
H302
References & Citations
[1]Choi BY, et al. Clofilium, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Cancer Lett. 1999 Dec 1;147 (1-2) :85-93.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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