Clofilium tosylate
Product Specifications
UNSPSC Description
Clofilium tosylate, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Antiarrhythmic agent[1].
Target Antigen
Apoptosis; Potassium Channel
Type
Reference compound
Related Pathways
Apoptosis;Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Clofilium_tosylate.html
Purity
99.84
Solubility
DMSO : 100 mg/mL (ultrasonic)|H2O : 1.59 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
CCCCCCC[N+](CC)(CCCCC1=CC=C(Cl)C=C1)CC.O=S(C2=CC=C(C)C=C2)([O-])=O
Molecular Weight
510.17
References & Citations
[1]Choi BY, et al. Clofilium, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Cancer Lett. 1999 Dec 1;147(1-2):85-93.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-33350/Clofilium-tosylate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-33350/Clofilium-tosylate-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
92953-10-1
Available Sizes
Curated Selection
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