Clofilium tosylate

Clofilium tosylate, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Antiarrhythmic agent[1].

Product Specifications

CAS Number

[92953-10-1]

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Potassium Channel

Type

Reference compound

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Clofilium_tosylate.html

Concentration

10mM

Purity

99.60

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 1.59 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CCCCCCC[N+](CC)(CCCCC1=CC=C(Cl)C=C1)CC.O=S(C2=CC=C(C)C=C2)([O-])=O

Molecular Formula

C28H44ClNO3S

Molecular Weight

510.17

Precautions

H302

References & Citations

[1]Choi BY, et al. Clofilium, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Cancer Lett. 1999 Dec 1;147 (1-2) :85-93.