H-D-Phe-Pip-Arg-pNA (hydrochloride)

H-D-Phe-Pip-Arg-pNA (S-2238) hydrochloride, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA hydrochloride is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III) . The AT-III assay using H-D-Phe-Pip-Arg-pNA hydrochloride is sensitive, accurate, and easy to perform[1][2].

Product Specifications

CAS Number

[160192-34-7]

Product Name Alternative

S-2238 (hydrochloride)

UNSPSC

12352209

Target

Fluorescent Dye

Type

Peptides

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/h-d-phe-pip-arg-pna-hydrochloride.html

Purity

99.40

Solubility

H2O : 250 mg/mL (ultrasonic)

Smiles

O=C([C@H](N)CC1=CC=CC=C1)N2[C@H](C(N[C@@H](CCCNC(N)=N)C(NC3=CC=C([N+]([O-])=O)C=C3)=O)=O)CCCC2.Cl

Molecular Formula

C27H37ClN8O5

Molecular Weight

589.09

References & Citations

[1]Goodnight SH Jr, et al. Measurement of antithrombin III in normal and pathologic states using chromogenic substrate S-2238. Comparison with immunoelectrophoretic and factor Xa inhibition assays. Am J Clin Pathol. 1980;73 (5) :639-647.|[2]van Voorthuizen H, Kluft C. Improved assay conditions for automated antithrombin III determinations with the chromogenic substrate S-2238. Thromb Haemost. 1984;52 (3) :350-353.