MK-2461

MK-2461 is an ATP-competitive, selective and orally active wild-type and mutant c-Met inhibitor (IC50s: 0.4-2.5 nM) . MK-2461 also inhibits Ron (IC50 of 7 nM) and Flt1 (IC50 of 10 nM), MK-2461 shows selective for c-MET over other kinases (lC50s = 22-7800 nM) . MK-2461 can be used for the study of cancer, such as gastric cancer[1].

Product Specifications

CAS Number

[917879-39-1]

UNSPSC

12352005

Hazard Statement

H317, H319

Target

C-Met/HGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/MK-2461.html

Concentration

10mM

Purity

99.28

Solubility

DMSO : ≥ 31 mg/mL

Smiles

O=S(N(C)C[C@H]1OCCOC1)(NC2=CC=C3C=CC(C(C(C3=C2)=O)=C4)=NC=C4C5=CN(N=C5)C)=O

Molecular Formula

C24H25N5O5S

Molecular Weight

495.55

Precautions

H317, H319

References & Citations

[1]Pan BS, et al. MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70 (4) :1524-33.