MK-2461
MK-2461 is an ATP-competitive, selective and orally active wild-type and mutant c-Met inhibitor (IC50s: 0.4-2.5 nM) . MK-2461 also inhibits Ron (IC50 of 7 nM) and Flt1 (IC50 of 10 nM), MK-2461 shows selective for c-MET over other kinases (lC50s = 22-7800 nM) . MK-2461 can be used for the study of cancer, such as gastric cancer[1].
Product Specifications
CAS Number
[917879-39-1]
UNSPSC
12352005
Hazard Statement
H317, H319
Target
C-Met/HGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/MK-2461.html
Concentration
10mM
Purity
99.28
Solubility
DMSO : ≥ 31 mg/mL
Smiles
O=S(N(C)C[C@H]1OCCOC1)(NC2=CC=C3C=CC(C(C(C3=C2)=O)=C4)=NC=C4C5=CN(N=C5)C)=O
Molecular Formula
C24H25N5O5S
Molecular Weight
495.55
Precautions
H317, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Citation 01
Sci Transl Med. 2018 Jul 18;10 (450) :eaaq1093.|J Cell Mol Med. 2025 Mar;29 (5) :e70486.
Available Sizes
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