FAPI-74

FAPI-74 is a PET (positron emission tomography) tracer targeting the fibroblast activation protein (FAP) . FAPI-74 can be used for FAP-positive tumor research[1][2].

Product Specifications

CAS Number

[2374782-76-8]

UNSPSC

12352005

Target

FAP

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fapi-74.html

Purity

99.84

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=NC(C=C2)=C1C=C2OCCCN(CC3)CCN3C(CN(CCN4CC(O)=O)CCN(CC4)CC(O)=O)=O)NCC(N(CCC5)[C@@H]5C#N)=O

Molecular Formula

C36H49N9O8

Molecular Weight

735.83

References & Citations

[1]Uwe Haberkorn, et al. Fap inhibitor. Patent, WO2019154886A1.|[2]Giesel FL, et al. FAPI-74 PET/CT Using Either 18F-AlF or Cold-Kit 68Ga Labeling: Biodistribution, Radiation Dosimetry, and Tumor Delineation in Lung Cancer Patients. J Nucl Med. 2021 Feb;62 (2) :201-207. |[3]Liu Y, et al. Fibroblast activation protein targeted therapy using [177Lu]FAPI-46 compared with [225Ac]FAPI-46 in a pancreatic cancer model. Eur J Nucl Med Mol Imaging. 2022 Feb;49 (3) :871-880.