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SRI-011381 (hydrochloride)

Product Specifications

UNSPSC Description

SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects[1][2].

Target Antigen

TGF-beta/Smad

Type

Reference compound

Related Pathways

Stem Cell/Wnt;TGF-beta/Smad

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/SRI-011381-hydrochloride.html

Purity

99.55

Solubility

DMSO : 33.33 mg/mL (ultrasonic)|H2O : 25 mg/mL (ultrasonic)

Smiles

O=C(NC1CCCCC1)N(CC2=CC=CC=C2)CC3CCNCC3.Cl[H]

Molecular Weight

365.94

References & Citations

[1]Jingyin Han, et al. The Improvement Effect of Sodium Ferulate on the Formation of Pulmonary Fibrosis in Silicosis Mice Through the Neutrophil Alkaline Phosphatase 3 (NALP3)/Transforming Growth Factor-β1 (TGF-β1)/α-Smooth Muscle Actin (α-SMA) Pathway. Med Sci Monit. 2021 Jun 15;27:e927978.|[2]Qian Wu, et al. Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling. Theranostics. 2021 Jul 25;11(17):8480-8499.Biomed Res Int. 2020 Nov 16;2020:8039840.|Biosci Rep. 2020 Nov 27;40(11):BSR20201545.|Cancer Cell Int. 2022 May 16;22(1):191.|Cell Commun Signal. 2023 Jul 4;21(1):168.|Cell Cycle. 2021 Jan 26;1-15.|Cell Mol Biol Lett. 2023 Feb 27;28(1):15.|Chem Res Toxicol. 2022 Feb 21;35(2):233-243.|Curr Med Sci. 2019 Aug;39(4):534-540.|Dev Comp Immunol. 2018 Nov;88:144-151. |Drug Dev Res. 2019 Nov;80(7):992-999. |Eur J Pharmacol. 2021 Oct 5;908:174356.|Evid Based Complement Alternat Med. 2023 Jan 12;2023:6018375.|Exp Eye Res. 2019 Mar 23;182:44-56.|J Cardiothorac Surg. 2024 May 10;19(1):283.|J Cell Mol Med. 2021 Apr;25(7):3272-3283.|J Ethnopharmacol. 2023 Dec 18:117507.|Laryngoscope. 2024 May 21.|Life Sci. 2021 Aug 15;279:119359.|Mol Cell Biochem. 2019 Jun;456(1-2):95-104. |Mol Med Rep. 2021 Nov;24(5):758.|Nature. 2023 Jan;613(7942):120-129.|Neurobiol Dis. 2024 Jun 18:199:106573.|Oncol Lett. 2024 May 30.|Phytomedicine. 1 June 2022, 154234.|Phytomedicine. 2022 Mar 21;100:154067.|Reprod Domest Anim. 2022 Oct 28.|Research Square Preprint. 2020 Dec.|Sci Rep. 2024 Oct 15;14(1):24091.|Stem Cells. 2024 May 8:sxae032.|Theranostics. 2021; 11(17):8480-8499.|Cell Immunol. 2023 Nov 2, 104781.|Cell Prolif. 2024 Oct 15:e13765.|Dis Markers. 2022 May 7;2022:9230647.|Int J Mol Sci. 2024 Nov 2;25(21):11778.|Int J Pharm X. 2024 Dec.|J Agric Food Chem. 2022 Aug 25.|J Cell Mol Med. 2024 Nov;28(21):e70199.|J Ethnopharmacol. 2024 Oct 1;337(Pt 2):118876.|Oncol Lett. 2024 Mar 26.|Phytother Res. 2022 Nov 28.|Sci China Life Sci. 2024 Oct 12.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-100347A/SRI-011381-hydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-100347A/SRI-011381-hydrochloride-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

2070014-88-7

Available Sizes

Curated Selection

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