GLP-1 (32-36) amide

GLP-1 (32-36) amide, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1 (32-36) amide could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice[1][2].

Product Specifications

CAS Number

[1417302-71-6]

UNSPSC

12352209

Target

GCGR

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/glp-1-32-36-amide.html

Purity

98.44

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

N=C(N)NCCC[C@@H](C(N)=O)NC(CNC([C@H](CCCCN)NC([C@H](C(C)C)NC([C@H](CC(C)C)N)=O)=O)=O)=O

Molecular Formula

C25H50N10O5

Molecular Weight

570.73

References & Citations

[1]Elahi D, et, al. GLP-1 (32-36) amide, a novel pentapeptide cleavage product of GLP-1, modulates whole body glucose metabolism in dogs. Peptides. 2014 Sep;59:20-4.|[2]Sun L, et, al. Novel Pentapeptide GLP-1 (32-36) Amide Inhibits β-Cell Apoptosis In Vitro and Improves Glucose Disposal in Streptozotocin-Induced Diabetic Mice. Chem Biol Drug Des. 2015 Dec;86 (6) :1482-90.|[3]Tomas E, et, al. GLP-1 (32-36) amide Pentapeptide Increases Basal Energy Expenditure and Inhibits Weight Gain in Obese Mice. Diabetes. 2015 Jul;64 (7) :2409-19.