PTP Inhibitor IV

PTP Inhibitor IV is a protein tyrosine phosphatase (PTP) inhibitor that competitively inhibits DUSP14 phosphatase activity with an 50 of 5.21 μM[1]. PTP Inhibitor IV inhibits SHP-2, PTP1B, PTP-ε, PTP Meg-2, PTP-σ, PTP-β, and PTP-μ with 50s of 1.8 μM, 2.5 μM, 8.4 μM, 13 μM, 20 μM, 6.4 μM, and 6.7 μM, respectively[2].

Product Specifications

CAS Number

[329317-98-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Phosphatase; SHP2

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ptp-inhibitor-iv.html

Purity

99.86

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

CC(C1=CC=C(C(C)(C2=CC=C(NS(C(F)(F)F)(=O)=O)C=C2)C)C=C1)(C3=CC=C(NS(C(F)(F)F)(=O)=O)C=C3)C

Molecular Formula

C26H26F6N2O4S2

Molecular Weight

608.62

Precautions

H302, H315, H319

References & Citations

[1]Jae Eun Park, et al. PTP inhibitor IV protects JNK kinase activity by inhibiting dual-specificity phosphatase 14 (DUSP14) . Biochem Biophys Res Commun. 2009 Oct 2;387 (4) :795-9. |[2]Ping Huang, et al. Structure-based design and discovery of novel inhibitors of protein tyrosine phosphatases. Bioorg Med Chem. 2003 Apr 17;11 (8) :1835-49.