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Febrifugine (dihydrochloride)

Febrifugine dihydrochloride is a quinazolinone alkaloid that inhibits P. falciparum and has antimalarial activity. Febrifugine dihydrochloride inhibits bladder cancer by inhibiting DNA synthesis, inducing apoptosis, and reducing steroids[1][2][3].

Product Specifications

CAS Number

32434-42-7

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; DNA/RNA Synthesis; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/febrifugine-dihydrochloride.html

Purity

99.95

Solubility

DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1N(CC(C[C@H]2NCCC[C@@H]2O)=O)C=NC3=C1C=CC=C3.Cl.Cl

Molecular Formula

C16H21Cl2N3O3

Molecular Weight

374.26

Precautions

H302

References & Citations

[1]Herman JD, et al. The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Sci Transl Med. 2015 May 20;7 (288) :288ra77.|[2]Murata K, et al. Potentiation by febrifugine of host defense in mice against Plasmodium berghei NK65. Biochem Pharmacol. 1999 Nov 15;58 (10) :1593-601.|[3]Chen J, et al. Discovery of anticancer function of Febrifugine: Inhibition of cell proliferation, induction of apoptosis and suppression steroid synthesis in bladder cancer cells. Toxicol Appl Pharmacol. 2024 Mar;484:116878.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

Plasmodium

Available Sizes

Frequently Asked Questions

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