Ganitumab
Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R) . Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (KD=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer[1].
Product Specifications
CAS Number
[905703-97-1]
Product Name Alternative
AMG 479; Human Anti-IGF1R Recombinant Antibody
UNSPSC
12352203
Target
IGF-1R
Type
Inhibitory Antibodies
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ganitumab.html
Purity
96.00
Solubility
10 mM in DMSO
Smiles
[Ganitumab]
Molecular Weight
(145.743 kDa)
References & Citations
[1]Moody G, et al. IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in mice. J Endocrinol. 2014 Mar 17;221 (1) :145-55.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 3
Available Sizes
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