NecroIr2
Product Specifications
UNSPSC Description
NecroIr2 is an iridium(III) complex, serves as necroptosis inducers in Cisplatin (HY-17394)-resistant lung cancer cells (A549R). NecroIr2 selectively accumulates in mitochondria, leading to oxidative stress and loss of mitochondrial membrane potential (MMP). NecroIr2 activates receptor-interacting serine-threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like pseudokinase (MLKL), and regulates CDK4 expression[1].
Target Antigen
CDK; Mixed Lineage Kinase; RIP kinase
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/necroir2.html
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C1(C2=NC(C=CC=C3)=C3O2)=CC(C4=[N]5C=CC(C6=NC(C=CC=C7)=C7O6)=C4)=[N]([Ir]89([N]%10=CC=CC=C%10C%11=C9C=CC=C%11)5[N]%12=CC=CC=C%12C%13=C8C=CC=C%13)C=C1.[Cl-]
Molecular Weight
926.44
References & Citations
[1]Guan R, et al. Necroptosis-inducing iridium (III) complexes as regulators of cyclin-dependent kinases[J]. Inorganic Chemistry Frontiers, 2021, 8(7): 1788-1794.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-148366/NecroIr2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-148366/NecroIr2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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