NecroIr2

NecroIr2 is an iridium (III) complex, serves as necroptosis inducers in Cisplatin (HY-17394) -resistant lung cancer cells (A549R) . NecroIr2 selectively accumulates in mitochondria, leading to oxidative stress and loss of mitochondrial membrane potential (MMP) . NecroIr2 activates receptor-interacting serine-threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like pseudokinase (MLKL), and regulates CDK4 expression[1].

Product Specifications

UNSPSC

12352300

Target

CDK; Mixed Lineage Kinase; RIP kinase

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/necroir2.html

Purity

98.99

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C1(C2=NC(C=CC=C3)=C3O2)=CC(C4=[N]5C=CC(C6=NC(C=CC=C7)=C7O6)=C4)=[N]([Ir]89([N]%10=CC=CC=C%10C%11=C9C=CC=C%11)5[N]%12=CC=CC=C%12C%13=C8C=CC=C%13)C=C1.[Cl-]

Molecular Formula

C46H30ClIrN6O2

Molecular Weight

926.44

References & Citations

[1]Guan R, et al. Necroptosis-inducing iridium (III) complexes as regulators of cyclin-dependent kinases[J]. Inorganic Chemistry Frontiers, 2021, 8 (7) : 1788-1794.