NecroIr2
NecroIr2 is an iridium (III) complex, serves as necroptosis inducers in Cisplatin (HY-17394) -resistant lung cancer cells (A549R) . NecroIr2 selectively accumulates in mitochondria, leading to oxidative stress and loss of mitochondrial membrane potential (MMP) . NecroIr2 activates receptor-interacting serine-threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like pseudokinase (MLKL), and regulates CDK4 expression[1].
Product Specifications
UNSPSC
12352300
Target
CDK; Mixed Lineage Kinase; RIP kinase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/necroir2.html
Purity
98.99
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
Molecular Formula
C46H30ClIrN6O2
Molecular Weight
926.44
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-148366/NecroIr2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-148366/NecroIr2-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK4; RIPK1; RIPK3
Available Sizes
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