NIM811

NIM811 ((Melle-4) cyclosporin; SDZ NIM811) is an orally bioavailable mitochondrial permeability transition and cyclophilin dual inhibitor, which exhibits potent in vitro activity against hepatitis C virus (HCV) [1][2].

Product Specifications

CAS Number

[143205-42-9]

Product Name Alternative

(Melle-4) cyclosporin; SDZ NIM811

UNSPSC

12352209

Target

Cyclophilin; HCV; Mitochondrial Metabolism

Type

Reference compound

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/NIM811.html

Purity

99.77

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C/C=C/C[C@H]([C@@H](O)[C@@]1(N(C)C([C@]([H])(C(C)C)N(C)C([C@H](CC(C)C)N(C)C([C@]([H])(CC(C)C)N(C)C([C@@H](C)NC([C@H](C)NC([C@@H](N(C([C@@]([H])(NC([C@@]([H])(N(C(CN(C([C@@H](NC1=O)CC)=O)C)=O)C)[C@H](CC)C)=O)C(C)C)=O)C)CC(C)C)=O)=O)=O)=O)=O)=O)[H])C

Molecular Formula

C62H111N11O12

Molecular Weight

1202.61

References & Citations

[1]Ma S, et al. NIM811, a cyclophilin inhibitor, exhibits potent in vitro activity against hepatitis C virus alone or in combination with alpha IFN. Antimicrob Agents Chemother. 2006 Sep;50 (9) :2976-82.|[2]Waldmeier PC, et al. Inhibition of the mitochondrial permeability transition by the nonimmunosuppressive cyclosporin derivative NIM811. Mol Pharmacol. 2002 Jul;62 (1) :22-9.|[3]Rehman H, et al. NIM811 prevents mitochondrial dysfunction, attenuates liver injury, and stimulates liverregeneration after massive hepatectomy. Transplantation. 2011 Feb 27;91 (4) :406-12.