Tomentosin

Tomentosin is an orally active natural sesquiterpenoid lactone. Tomentosin exhibits multiple activities such as anti-tumor, anti-fungal, anti-inflammatory, anti-oxidant and neuroprotective effects. Tomentosin can inhibit tumor cell proliferation, migration and invasion, and induce apoptosis. Tomentosin can be used in the research of tumors, inflammation and nervous system diseases[1][2][3][4].

Product Specifications

CAS Number

[33649-15-9]

UNSPSC

12352005

Target

Apoptosis; Fungal; Interleukin Related; Keap1-Nrf2; NF-κB; Reactive Oxygen Species (ROS) ; SOD; Toll-like Receptor (TLR)

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tomentosin.html

Purity

98.95

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C=C1[C@](CC=C2CCC(C)=O)([H])[C@@](OC1=O)([H])C[C@@H]2C

Molecular Formula

C15H20O3

Molecular Weight

248.32

References & Citations

[1]Güçlü E, et al. Tomentosin induces apoptosis in pancreatic cancer cells through increasing reactive oxygen species and decreasing mitochondrial membrane potential. Toxicol In Vitro. 2022 Oct;84:105458.|[2]Cafarchia C, et al. Attività fungistatica di un sesquiterpene lattone (tomentosina) isolato dai fiori freschi di Inula viscosa (Asteraceae) della regione Puglia [Fungistatic activity of a sesquiterpene lactone (tomentosin) isolated from fresh Inula viscosa (Asteraceae) flowers from the Puglia region]. Parassitologia. 2001 Sep;43 (3) :117-21. Italian.|[3]Fan Y, et al. Tomentosin Reduces Behavior Deficits and Neuroinflammatory Response in MPTP-Induced Parkinson's Disease in Mice. J Environ Pathol Toxicol Oncol. 2021;40 (1) :75-84.|[4]Güvenç M, et al. Tomentosin mitigates the LPS induced cardiac injury by regulating Nrf-2/Nf-κβ pathway in mice. Eur J Pharmacol. 2025 Jun 5;996:177589.