(S, R, S) -AHPC- (C3-PEG) 2-C6-Cl
(S, R, S) -AHPC- (C3-PEG) 2-C6-Cl is a small molecule HaloPROTAC that incorporates the (S, R, S) -AHPC based VHL ligand and 2-unit PEG linker. (S, R, S) -AHPC- (C3-PEG) 2-C6-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
Product Specifications
CAS Number
[1835705-61-7]
Product Name Alternative
VHL Ligand-Linker Conjugates 11; E3 ligase Ligand-Linker Conjugates 11
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/E3_ligase_Ligand-Linker_Conjugates_11.html
Purity
99.89
Solubility
DMSO : 200 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)CCCCCOCCCCCOCCCCCCCl
Molecular Formula
C39H61ClN4O6S
Molecular Weight
749.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Ashton C. Lai, et al. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11; 55 (2) : 807–810.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C, protect from light, stored under nitrogen
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
Available Sizes
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