Diosmetin-7-O-β-D-glucopyranoside

Diosmetin-7-O-β-D-glucopyranoside is a natural product that can be isolated from the flowers of Chrysanthemum morifolium. Diosmetin-7-O-β-D-glucopyranoside has potent antiviral and anti-inflammatory activities against SARS-CoV-2 both in vitro (IC50 = 0.74 μM) and in vivo. Diosmetin-7-O-β-D-glucopyranoside has significant anti-thrombotic activity when combined with Pae and 5-HMF at a ratio of 3:4:3 in a zebrafish model[1][2][3].

Product Specifications

CAS Number

[20126-59-4]

UNSPSC

12352005

Hazard Statement

H302

Target

Interleukin Related; NF-κB; SARS-CoV

Type

Natural Products

Related Pathways

Anti-infection; Immunology/Inflammation; NF-κB

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/diosmetin-7-o-beta-d-glucopyranoside.html

Purity

99.61

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C=C(C1=CC(O)=C(OC)C=C1)OC2=CC(O[C@@H]([C@@H]([C@@H](O)[C@@H]3O)O)O[C@@H]3CO)=C4)C2=C4O

Molecular Formula

C22H22O11

Molecular Weight

462.40

Precautions

H302

References & Citations

[1]Wang YJ, et al. Studies on chemical constituents in Huangjuhua (flowers of Chrysanthemum morifolium. Zhongguo Zhong Yao Za Zhi. 2008 Mar;33 (5) :526-30.|[2]Mingshun Chen, et al. An HPLC-DPPH method for antioxidant activity from sugarcane molasses. Zuckerindustrie. Sugar industry. 2015 Oct;140 (10) :632-639.|[3]Xu, Y. L., et al., (2025) . Diosmetin-7-O-β-D-glucopyranoside from Pogostemonis Herba alleviated SARS-CoV-2-induced pneumonia by reshaping macrophage polarization and limiting viral replication. Journal of ethnopharmacology, 336, 118704.