Mexiletine (hydrochloride)

Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC50 : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research[1][2][3][4][5].

Product Specifications

CAS Number

[5370-01-4]

Product Name Alternative

KOE-1173 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Mexiletine-hydrochloride.html

Concentration

10mM

Purity

99.88

Solubility

DMSO : ≥ 41 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

CC(N)COC1=C(C)C=CC=C1C.[H]Cl

Molecular Formula

C11H18ClNO

Molecular Weight

215.72

Precautions

H302, H315, H319, H335

References & Citations

[1]Campbell RW, et al. Mexiletine. N Engl J Med. 1987, 316 (1) :29-34.|[2]De Bellis M, et al. Combined modifications of mexiletine pharmacophores for new lead blockers of Na (v) 1.4 channels. Biophys J. 2013, 104 (2) :344-54.|[3] Nasilli G, et al. Mexiletine reverses oxaliplatin-induced neuropathic pain in rats. J Pharmacol Sci. 2010;112 (4) :473-6.|[4]Egashira N, et al. Mexiletine reverses oxaliplatin-induced neuropathic pain in rats. J Pharmacol Sci. 2010, 112 (4) :473-6.