PAWI-2
PAWI-2 is a p53-Activator and Wnt Inhibitor. PAWI-2 inhibits β3-KRAS signaling independent of KRAS. PAWI-2 selectively inhibits phosphorylation of TBK1. PAWI-2 activates apoptosis (activation of caspase-3/7), and induces PARP cleavage. PAWI-2 promotes optineurin translocation into the nucleus and causes G2/M arrest. PAWI-2 reverses cancer stemness and overcomes drug resistance in an integrin β3 KRAS-dependent human pancreatic cancer stem cells (hPCSCs) . PAWI-2 inhibits growth of tumors from hPCSCs in orthopic xenograft mice model[1][2].
Product Specifications
CAS Number
[1448427-02-8]
UNSPSC
12352005
Target
Apoptosis; Caspase; IKK; MDM-2/p53; Wnt
Type
Reference compound
Related Pathways
Apoptosis; NF-κB; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pawi-2.html
Purity
99.29
Smiles
O=C1N(C2=CC=C(S(=O)(N3CCN(C)C4=C3C=CC=C4)=O)C=C2)CCC1
Molecular Formula
C19H21N3O3S
Molecular Weight
371.45
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 7
Available Sizes
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