MK-0557
MK-0557 is a highly selective, orally available neuropeptide Y5 receptor antagonist with a Ki of 1.6 nM.
Product Specifications
CAS Number
[328232-95-7]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Neuropeptide Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/MK-0557.html
Concentration
10mM
Purity
99.80
Solubility
DMSO : 175 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
O=C([C@H]1CC[C@@](C2=C3C=CN=C2)(OC3=O)CC1)NC4=NN(C5=CC=CC=C5F)C=C4
Molecular Formula
C22H19FN4O3
Molecular Weight
406.41
Precautions
H315, H319, H335
References & Citations
[1]Fichtner M, et al. Discovery and evaluation of spirocyclic derivatives as antagonists of the neuropeptide Y5 receptor. Bioorg Med Chem Lett. 2012 Apr 15;22 (8) :2738-43.|[2]Erondu N, et al. Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults. Cell Metab. 2006 Oct;4 (4) :275-82.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
NPY Y5 receptor
Available Sizes
Curated Selection
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