MK-0557

MK-0557 is a highly selective, orally available neuropeptide Y5 receptor antagonist with a Ki of 1.6 nM.

Product Specifications

CAS Number

[328232-95-7]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Neuropeptide Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/MK-0557.html

Concentration

10mM

Purity

99.80

Solubility

DMSO : 175 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C([C@H]1CC[C@@](C2=C3C=CN=C2)(OC3=O)CC1)NC4=NN(C5=CC=CC=C5F)C=C4

Molecular Formula

C22H19FN4O3

Molecular Weight

406.41

Precautions

H315, H319, H335

References & Citations

[1]Fichtner M, et al. Discovery and evaluation of spirocyclic derivatives as antagonists of the neuropeptide Y5 receptor. Bioorg Med Chem Lett. 2012 Apr 15;22 (8) :2738-43.|[2]Erondu N, et al. Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults. Cell Metab. 2006 Oct;4 (4) :275-82.