CHMFL-BMX-078
CHMFL-BMX-078 is a highly potent and selective type II irreversible BMX kinase inhibitor with an IC50 of 11 nM.
Product Specifications
CAS Number
1808288-51-8
Product Name Alternative
CHMFL-BMX 078
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
BMX Kinase
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CHMFL-BMX-078.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : ≥ 30 mg/mL
Smiles
O=C(C1=CN=C(NC2=CC=C(C)C(NC(C=C)=O)=C2)N=C1NC)NC3=CC(NC(C4=CC(OC)=C(OC)C(OC)=C4)=O)=CC=C3C
Molecular Formula
C33H35N7O6
Molecular Weight
625.67
Precautions
H302, H315, H319, H335
References & Citations
[1]Liang X, et al. Discovery of 2- ((3-Acrylamido-4-methylphenyl) amino) -N- (2-methyl-5- (3,4,5-trimethoxybenzamido) phenyl) -4- (methylamino) pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome (BMX) Kinase Inhibitor. J Med Chem. 2017 Mar 9;60 (5) :1793-1816.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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