AS1517499
AS1517499 is a potent and brain-permeable STAT6 phosphorylation inhibitor with an IC50 of 21 nM.
Product Specifications
CAS Number
919486-40-1
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/AS1517499.html
Concentration
10mM
Purity
99.17
Solubility
DMSO : ≥ 35 mg/mL
Smiles
O=C(C1=CN=C(NCCC2=CC=C(O)C(Cl)=C2)N=C1NCC3=CC=CC=C3)N
Molecular Formula
C20H20ClN5O2
Molecular Weight
397.86
Precautions
H302, H312, H332
References & Citations
[1]Nagashima S, et al. Synthesis and evaluation of 2-{[2- (4-hydroxyphenyl) -ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors. Bioorg Med Chem. 2007 Jan 15;15 (2) :1044-55.|[2]Chiba Y, et al. A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice. Am J Respir Cell Mol Biol. 2009 Nov;41 (5) :516-24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT6
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LY400261 100 µg
Cytochrome P450 2C8 (CYP2C8) (NM_000770) Human Over-expression Lysate
Sign In for Pricing
View Details 
BNC402579-100 1x 100 µL
CD10 (Membrane Metalloendopeptidase) (MME/2579), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details